Does gum disease have a key role in Alzheimer’s?

(BBC) – Does gum disease play a key role in the development of Alzheimer’s?

Scientists believe this may be the case after their study found further evidence of the link between bacteria in a common type of gum disease and people with dementia.

Researchers say their findings offer hope for a new way of tackling the illness, for which there is no cure and no effective treatments.

But does it mean people should be more worried about their oral health?

What did the research find?

Scientists analysed brain tissue, spinal fluid, and saliva from dead and living patients with diagnosed and suspected Alzheimer’s.

Their study, published in the journal Science Advances, found bacteria associated with chronic gum disease, Porphyromonas gingivalis, in the brains of people with Alzheimer’s.

Tests on mice confirmed the bacteria could travel from the mouth to the brain and showed the toxic protein they secrete, called gingipain, destroyed brain neurons.

The bacteria also increased production of amyloid beta, a component of the amyloid plaques commonly associated with Alzheimer’s.

Following this, scientists tested drugs in mice aimed at blocking the toxic proteins and found they were able to halt degeneration in the brain.

The authors of the study concluded: “The findings of this study offer evidence that Porphyromonas gingivalis and gingipains in the brain play a central role in the pathogenesis [development] of AD [Alzheimer’s disease], providing a new conceptual framework for disease treatment.”

The team has now developed a new drug they hope could form the basis of a human treatment and plan to test it in people with mild to moderate Alzheimer’s, in a clinical trial, later this year.

ToothpastesImage copyrightGETTY IMAGES

What do other scientists say about the study?

Scientists not involved in the research said it added to the evidence of the link between gum disease and dementia, the umbrella term for brain conditions that include Alzheimer’s.

But they say it is still not clear what role gum disease bacteria has in the development of Alzheimer’s.

People with Alzheimer’s are more susceptible to getting infections in their brains, so it may be that the gum disease bacteria and the toxic proteins they secrete are a by-product of Alzheimer’s rather than a cause.

There was also caution about the fact the drug tests had been in mice.

Prof Tara Spires-Jones, from the UK Dementia Research Institute, at the University of Edinburgh, said it was “great news” that the study provided evidence these drugs may affect Alzheimer’s-related proteins.

“However, we will have to await the larger clinical trial to see if it will be beneficial to people living with Alzheimer’s disease,” she said.

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