COVID-19 Vaccine: Cuba's Among Top 30 Worldwide Candidates

The capacity to generate particular antibodies against the virus only seven days after the first dose is one of the most outstanding qualities of the SOBERANA vaccine candidate.

Cuban science authorities confirmed on Thursday that the vaccine candidate FINLAY-FR-1 would be commercialized under the name of SOBERANA once it finishes the clinical trials successfully, which are slated to start on August 24.

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During an interview with national television program Mesa Redonda, Finlay Vaccine Institute (IFV) director Vicente Vérez explained that Cuba’s vaccine candidate is the number 30th to receive approval to go on clinical trials among 200 vaccines candidates worldwide.

“This is a milestone for Cuba’s science, being able to come up with a vaccine candidate that’s qualified to go on clinical trials and to achieve that in only 90 days”, Vérez said as the average time to develop a vaccine candidate takes 10 to 15 years.

On the other hand, Yuri Valdéz Balbín deputy director at IFV detailed that the Soberana vaccine candidate is based on the protein RBD, an antigen that acts as a “key” to access the virus. This protein requires mammals cells based technology to be produced, something that Cuba’s’s Center for Molecular Immunology has widely develop for other products such as cancer vaccines.

The scientist remarked that the speedy development of this vaccine candidate was possible because, unlike other circumstances, in the context of the COVID-19 pandemic, all scientific information can be accessed for free. Furthermore, Cuba’s decade’s long experience in vaccine production allowed it to use existing platforms rather than start from cero.

The research director at IVF Dagmar García noticed that during the preclinical trial in mouses, rabbits, and hamsters, it emerged that seven days after the firsts dose, the levels of specifical antibodies against the RBD protein rose considerably. In this sense, the scientist explained that the capacity to generate particular antibodies against the virus only seven days later is one of the most outstanding qualities of this vaccine candidate.

The platform for the SOBERANA vaccine was created based on the Cuban Meningogococcal Vaccine, which has been used since its creation in 1989. In this sense, and unlike some medical approaches worldwide, Cuban scientists decided that the clinical trials will use the Meningococcal Vaccine for the control groups.

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